Sox10 is a dynamically regulated transcription factor gene that is essential here for the development of neural crest-derived and oligodendroglial populations.Developmental genes often require multiple regulatory sequences that integrate discrete and overlapping functions to coordinate their expression.To identify Sox10 cis-regulatory elements, we
The "Magude project" aimed but failed to interrupt local malaria transmission in Magude district, southern Mozambique, by using a comprehensive package of interventions, including indoor residual spraying (IRS), pyrethroid-only long-lasting insecticide treated nets (LLINs) and mass-drug administration (MDA).Here we arcade smokey the bear belt prese
Raju Dash,1 Rasel Das,2 Md Junaid,3 Md Forhad Chowdhury Akash,4 Ashekul Islam,5 SM arcade smokey the bear belt Zahid Hosen1 1Molecular Modeling and Drug Design Laboratory (MMDDL), Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research (BCSIR), Chittagong, Bangladesh; 2Nanotechnology and Catalysis Research Center, U
Costimulation with the recombinant SA-4-1BBL agonist of 4-1BB receptor on conventional CD4+ T cells (Tconvs) overcomes the suppression mediated by naturally occurring CD4+CD25+FoxP3+ T regulatory cells (Tregs).The mechanistic basis of this observation has remained largely unknown.Herein we show that Tconvs, but not Tregs, are the direct target dori
Vertical take-off and landing (VTOL) aircraft have become important aerial vehicles for various sectors, such as security, health, and commercial sectors.These vehicles are capable of operating in different flight modes, allowing for the covering of most flight requirements in most environments.A tail-sitter aircraft is a type of VTOL vehicle super